Welcome to the home page of

   Department of Pathology and Oncology 

      Juntendo University School of Medicine!​

We study stromal fibroblasts present in tumor-associated stroma. 

Akira Orimo, Professor, Juntendo University 

CAFs (carcinoma-associated fibroblasts) are composed of myofibroblasts, a hallmark of activated fibroblasts, and quiescent fibroblasts. Significant heterogeneity in stromal fibroblast populations of tumor stroma indicates their distinct biological roles. Tumor-promoting CAFs boost invasion and metastasis as well as drug resistance in apposed carcinoma cells. Once established, such tumor-promoting ability is stably maintained without the ongoing interaction with carcinoma cells, indicating that tumor-promoting CAFs are a promising therapeutic target. We focus on investigating the CAFs’ origin, CAFs differentiation process from their progenitors and CAF-tumor cell interactions at molecular levels.

INFORMATION

March 1, 2020 Dr. Akira Orimo  was appointed to a professorship at the Department of Pathology and Oncology, Juntendo University.        New!!

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Jan 22, 2020 Dr. Akira Orimo lectured to 7 students from National Defense Medical Center programmed by AMSA (Asian Medical Students'Association (https://amsajapan.wixsite.com/amsajapan)) on cancer biology.  New!!

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Dec 20, 2019 Dr Akira Orimo has been informed to receive the Takamatsu Miyazaki Cancer Research Fund grant for 2019.

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Nov 6, 2019 A press release for Mizukoshi et al., International Journal of Cancer, has been issued from the Juntendo University as "Elucidation of new metastasis mechanism of colorectal cancer.(https://www.juntendo.ac.jp/news/20191106-01.html

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Aug 27, 2019 A press release for Matsumura et al., Life Science Alliance, has been issued from the Juntendo University as "Discovering a new mechanism to promote breast cancer invasion and metastasis".

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Aug 26, 2019 Mizukoshi K. et al., research article has been accepted by International Journal of Cancerhttps://onlinelibrary.wiley.com/doi/10.1002/ijc.32672

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July 21, 2019 Matsumura Y. et al., research article has been published by Life Science Alliance.  

https://www.life-science-alliance.org/content/2/4/e201900425

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May 3, 2019 Yoshida G. et al., have been accepted by International Journal of Molecular Sciences.  

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April 21 2019 Mezawa Y. et. al., have been accepted by Cancer Medicine.  

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April 2019  The research program of Yoshihiro Mezawa (2nd year PhD student) was awarded by The Tokyo Biochemical Research Foundation.

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April 1 2019  Dr. Shoki Okubo, Assistant Professor, Dept. of Gastroenterology, Juntendo Univ. has been funded by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan (Research Project Number: 19K16754).  

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Nov 28, 2018 Invited lecture from Prof. Ittai Ben-Porath, The Hebrew University–Hadassah Medical School, Jerusalem, Israel . 

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April 2018  The research program of Yoshihiro Mezawa (1st year PhD student) was awarded by The Tokyo Biochemical Research Foundation. 

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