Department of Pathology and Oncology
Juntendo University School of Medicine
順天堂大学 病理・腫瘍学講座
Publications
https://scholar.google.com/citations?user=U3)xcHeYAAAAJ&hl=ja&user=kawcbvEAAAAJ
2024
原著論文
neoadjuvant chemotherapy-treated pancreatic cancer. Jpn. J. Clin. Oncol. 2024
https://doi.org/10.1093/jjco/hyae118 *Corresponding author
総説
1. Shirakihara T and Orimo A: Activin A from primary breast tumors generates a pre-metastatic
niche by inducing pulmonary fibrosis. Translational Brest Cancer Research,
2. 目澤義弘、折茂彰：がん関連線維芽細胞の多様性と浸潤・転移促進メカニズム。
実験医学、2024年7月号 DOI: 10.18958/7511-00001-0001642-00
2023
原著論文
1. Mezawa Y, Wang T, Daigo Y, Takano A, Miyagi Y, Yokose T, Yamashita T, Yang L,
Maruyama R, Seimiya H, Orimo A.*: Glutamine deficiency drives TGF-β signaling
activation that gives rise to myofibroblastic carcinoma-associated fibroblasts.
Cancer Science, 2023. DOI: 10.1111/cas.15955 *Corresponding author
順天堂大学よりプレスリリースされました。https://www.juntendo.ac.jp/news/15741.html
がん関連線維芽細胞の新たな誘導メカニズムを発見｜ニュース＆イベント｜順天堂大学
juntendo.ac.jp
がん関連線維芽細胞の新たな誘導メカニズムを発見｜ニュース＆イベント｜順天堂大学
順天堂大学・大学院の公式サイトです。医学部、スポーツ健康科学部、医療看護部、
保健看護学部、国際教養学部、保健医療学部・医療科学部・健康データサイエンスの
8学部と医学研究科、スポーツ健康研究科、医療看護研究科の３研究科そして6医学部附属
病院からなる健康総合大学・大学院大学として教育・研究・医療を通じて社会貢献を進めております。
（PDF）
2. Koyama Y, Okazaki H, Yang S, Mezawa Y, Wang Z, Sakimoto M, Ishizuka A, Ito Y,
Koyama T, Daigo Y, Takano A, Miyagi Y, Yokose T, Yamashita T, Sugahara K, Hino O,
Yang L, Maruyama R, Katakura A, Yasukawa T*, Orimo A.*: Increased RUNX3
expression mediates tumor-promoting ability of human breast cancer-associated
fibroblasts. Cancer Med., 2023. DOI: 10.1002/cam4.6421 *Corresponding author
（PDF）
3. Vail M.E, Farnsworth R.H, Hii L, Allen S, Arora S, Anderson R.L, Dickins R.A, Orimo A, Wu S.Z,
Swarbrick A, Scott A.M, Janes P.W.: Inhibition of EphA3 expression in tumour stromal cells
suppresses tumour growth and progression. Cancers, 2023.
4. Koyanagi A, Kajino K, Nojiri S, Abe M, Kobayashi T, Sugitani Y, Yue L, Ohtsuji N,
Arakawa A, Sato T, Takahashi K, Suzuki K, Orimo A, Yao T, Hino O.: Serum levels of
N- and C-ERC/Mesothelin and clinicopathological factors in mesothelioma patients
and those without mesothelioma. Juntendo Medical J. 69(2): 124-136, 2023
5. Fushimi T, Kobayashi T, Itoh H.: CEP164-GLI2 association ensures the hedgehog
signaling in pancreatic cancer cells. Biochem. Biophys. Res. Commun. 666: 179-185 (2023)
総説
1. Escudero-Esparza A, Bartoschek M, Gialeli C, Okraj M, Owen S, Jirström K, Orimo A, Jiang
W.G., Pietras K and Blom A.M.: Correction: Complement inhibitor CSMD1 acts as tumor
suppressor in human breast cancer. Oncotarget, 2023, 14:481-482. Doi: 10.18632/oncotarget.28426
著書
1. Yasukawa T.* & Kang D. (2023) Assessing TFAM Binding to Human Mitochondrial DNA. Methods in Molecular Biology. Vol. 2615, pp. 139-151. 【*corresponding author】
学会発表
1. Yasukawa T., Matsuda S., Do Y., Nakayama M., Inatomi T., Ishiuchi T., Nakada K., Ichiyanagi K., Sasaki H., Kang D.：Mechanism of mammalian mitochondrial DNA replication. 第22回日本ミトコンドリア学会、招待公演、2023年11月
2022
原著論文
1. Tani H, Ishikawa K, Tamashiro H, Ogasawara, E, Yasukawa T, Matsuda, S, Shimizu A, Kang D, Hayashi JI, Wei FY, Nakada K (2022) Aberrant RNA processing contributes to the pathogenesis of mitochondrial diseases in trans-mitochondrial mouse model carrying mitochondrial tRNALeu(UUR) with a pathogenic A2748G mutation. Nucleic Acids Res. 50(16) 9382-9396.
2. Taniguchi G, Kajino K, Momose S, Saeki H, Yue L, Ohtsuji N, Abe M, Shibuya T, Orimo A, Nagahara A, Watanabe S, Hino O (2022) The Inhibitory Effects of Anti-ERC/Mesothelin Antibody 22A31 on Colorectal Adenocarcinoma Cells, within a Mouse Xenograft Model. Cancers 28;14(9):2198.
3. Inatomi, T, Matsuda, S, Ishiuchi, T, Do Y, Nakayama, M, Abe S, Kasho K, Wanrooij S, Nakada, K, Ichiyanagi K, Sasaki H, Yasukawa T*, Kang D (2022) TFB2M and POLRMT are essential for mammalian mitochondrial DNA replication. Biochim. Biophys. Acta - Molecular Cell Research 1869(1), 119167. 【*corresponding author】
4. Nomiyama, T, Setoyama, D, Yasukawa T, Kang D (2022) Mitochondria metabolomics reveals a role of β-nicotinamide mononucleotide metabolism in mitochondrial DNA replication. J. Biochem. 171(3) 325-338.
総説等（2021も含む）
5. 安川 武宏、康 東天 （2022）ミトコンドリアDNAの複製・維持機構と関連疾患 医学のあゆみ 281(12), 1121-1127.
6. 目澤 義弘、折茂 彰 (2022) Carcinoma-associated fibroblastsによるがん細胞分化プログラムの制御 臨床免疫・アレルギー科：144-151.
7. 安川 武宏（2021） ミトコンドリアゲノムの複製・維持 ミトコンドリアダイナミクス 第４章第３節 pp121-129.
8. 富永 香奈、折茂 彰（2021） 癌内線維芽細胞の不均一性と癌促進作用 実験医学 39, 55-60.
2021
1. Martínez-López A, García-Casas A, Bragado P, Orimo A, Castañeda-Saucedo E, Castillo-Lluva S. Inhibition of RAC1 activity in cancer associated fibroblasts favours breast tumour development through IL-1β upregulation. (2021)Cancer Lett. 19:S0304-3835(21)00403-1. doi: 10.1016/j.canlet.2021.08.014.（PDF）
2. Mezawa Y and Orimo A*., Phenotypic heterogeneity, stability and plasticity in tumor-promoting carcinoma-associated fibroblasts. (2021)FEBS J. doi: 10.1111/febs.15851. *Corresponding author（PDF）
3. Iwai M, Tulafu M, Togo S, Kawaji H, Kadoya K, Namba Y, Jin J, Watanabe J, Okabe T, Hidayat M, Sumiyoshi I, Itoh M, Koyama Y, Ito Y, Orimo A, Takamochi K, Oh S, Suzuki K, Hayashizaki Y, Yoshida K, Takahashi K. (2021) Cancer-associated fibroblast migration in non-small cell lung cancers is modulated by increased integrin α11 expression. Mol Oncol. doi: 10.1002/1878-0261.12937. （PDF）
2020
1. Okabe T, Togo S, Fujimoto Y, Watanabe J, Sumiyoshi I, Orimo A, Takahashi K.(2020) Mesenchymal Characteristics and Predictive Biomarkers on Circulating Tumor Cells for Therapeutic Strategy. Cancers, 12(12):3588. doi: 10.3390/cancers12123588.
（PDF）
2. Blanco-Gómez A, Hontecillas-Prieto L, Corchado-Cobos R, García-Sancha N, Salvador N, Castellanos-Martín A, Sáez-Freire MDM, Mendiburu-Eliçabe M, Alonso-López D, De Las Rivas J, Lorente M, García-Casas A, Del Carmen S, Abad-Hernández MDM, Cruz-Hernández JJ, Rodríguez-Sánchez CA, Claros-Ampuero J, García-Cenador B, García-Criado J, Orimo A, Gridley T, Pérez-Losada J, Castillo-Lluva S. (2020) Stromal SNAI2 is required for ERBB2 breast cancer progression. Cancer Res. 80(23):5216-5230. 2020 doi: 10.1158/0008-5472.CAN-20-0278. （PDF）
3. Mizukoshi K, Okazawa Y, Haeno H, Koyama Y, Sulidan K, Komiyama H, Saeki H, Ohtsuji N, Ito Y, Kojima Y, Goto M, Habu S, Hino O, Sakamoto K*,Orimo A.* (2020) Metastatic seeding of human colon cancer cell clusters expressing the hybrid epithelial/mesenchymal state. International Journal of Cancer, 146, 2547-2562. doi: 10.1002/ijc.32672. *Corresponding author （PDF）
順天堂大学よりプレスリリースされました⇒
https://www.juntendo.ac.jp/news/20191106-01.html
2019
1. Matsumura Y., Ito Y., Mezawa Y., Sulidan K., Daigo Y., Hiraga T., Mogushi K., Wali N., Polanska UM.,Suzuki H., Itoh T., Miyagi Y., Yokose T., Shimizu S., Takano A., Terao Y., Saeki H., Ozawa M., Abe M., Takeda S., Okumura K., Habu S., Hino O., Takeda K., Hamada M., and Orimo A.* (2019) Stromal fibroblasts induce metastatic tumor cell clusters via epithelial-mesenchymal plasticity.Life Science Alliance, 22;2(4):e201900425. doi: 10.26508/lsa.201900425. *Corresponding author （PDF）
順天堂大学よりプレスリリースされました⇒
https://www.juntendo.ac.jp/news/20190827-01.html
2. Go J. Yoshida*, Arata Azuma*, Yukiko Miura, Akira Orimo*
Activated fibroblast program orchestrates tumor initiation and progression; Molecular mechanisms and the associated therapeutic strategies. (2019) Int J Mol Sci., 20(9):2256. doi: 10.3390/ijms20092256. （PDF）
3. Mezawa Y., Daigo Y., Takano A., Miyagi Y., Yokose T., Yamashita T., Morimoto T., Hino O., and Orimo A.,* (2019) CD26 expression is attenuated by TGF-β and SDF-1 autocrine signaling on stromal myofibroblasts in human breast cancers. Cancer Med. 8(8):3936-3948. doi: 10.1002/cam4.2249. * Corresponding author （PDF）
～2018
1. Yu Okazawa, Kosuke Mizukoshi, Yu Koyama, Shoki Okubo, Hiromitsu Komiyama, Yutaka Kojima, Michitoshi Goto, Sonoko Habu, Okio Hino, Kazuhiro Sakamoto* and Akira Orimo* (2018) High-sensitivity detection of micrometastases generated by GFP lentivirus-transduced organoids cultured from a patient-derived colon tumor. Journal of Visualized Experiments. 14;(136). doi:10.3791/57374. * Corresponding author
2. Pernilla Roswall, Matteo Bocci, Michael Bartoschek, Hong Li, Glen Kristiansen, Sara Jansson, Sophie Lehn, Jonas Sjölund, Steven Reid, Christer Larsson, Pontus Eriksson, Charlotte Anderberg, Eliane Cortez, Lao H Saal, Christina Orsmark-Pietras, Eugenia Cordero, B Kristian Haller, Jari Häkkinen, Ingrid JG Burvenich, Elgene Lim, Akira Orimo, Mattias Höglund, Lisa Rydén, Holger Moch, Andrew M Scott, Ulf Eriksson, Kristian Pietras, (2018) Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling., Nature Medicine. doi: 10.1038/nm.4494.
3. Tomokatsu Omoto, Joo-ri Kim-Kaneyama, Xiao-Feng Lei, Akira Orimo, Koji Ohnishi, Kosuke Yoshihara, Aya Miyauchi, Shuo Li, Lin Gao, Takahiro Umemoto, Junichi Tanaka, Kenta Nakahara, Motohiro Takeya, Fumio Ishida, Shin-ei Kudo, Shogo Haraguchi, Takuro Miyazaki and Akira Miyazaki. (2017) The impact of stromal Hic-5 on the tumorigenesis of colorectal cancer through lysyl oxidase induction and stromal remodeling. Oncogene, doi: 10.1038/s41388-017-0033-y
4. Nakaoka HJ, Tanei Z, Hara T, Weng JS, Kanamori A, Hayashi T, Sato H, Orimo A, Otsuji K, Tada K, Morikawa T, Sasaki T, Fukayama M, Seiki M, Murakami Y, Sakamoto T. (2017) Mint3-mediated L1CAM expression in fibroblasts promotes cancer cell proliferation via integrin α5β1 and tumour growth. Oncogenesis. 6(5):e334.
5. Namba Y, Togo S, Tulafu M, Kadoya K, Nagahama KY, Taka H, Kaga N, Orimo A, Liu X, Takahashi K. (2017) Combination of glycopyrronium and indacaterol inhibits carbachol-induced ERK5 signal in fibrotic processes., Respir Res. 18, 46.
6. Escudero-Esparza A., Bartoschek M., Gialeli C., Okroj M., Owen S., Jirström K., Orimo A., Jiang WG., Pietras K., Blom AM., (2016) Complement inhibitor CSMD1 acts as tumor suppressor in human breast cancer. Oncotarget, 2016, 7, 76920-76933
7. Mezawa, Y. and Orimo A*., The roles of tumor- and metastasis-promoting carcinoma-associated fibroblasts in human carcinomas. Cell and tissue research, (2016), 365, 675-89. doi: 10.1007/s00441-016-2471-1. * Corresponding author
8. Englund E, Bartoschek M, Reitsma B, Jacobsson L, Escudero-Esparza A, Orimo A, Leandersson K, Hagerling C, Aspberg A, Storm P, Okroj M, Mulder H, Jirström K, Pietras K, Blom AM. (2016) Cartilage oligomeric matrix protein contributes to the development and metastasis of breast cancer. Oncogene. 235, 5585-5596 doi: 10.1038/onc.2016.98
9. Holmquist E., Reitsma B., King B., Escudero-Esparza Sioned Owen A., Orimo A., Okroj M., Anagnostaki L., Jiang W., Jirström K., Blom A., The human complement inhibitor Sushi Domain-Containing Protein 4 (SUSD4) expression in tumor cells and CD8+ T cells is associated with better prognosis of breast cancer patients. BMC Cancer, (2015) 19, 737.
10. Orimo A., (2014) The biology of tumour metastasis, Lecture Note, Juntendo Medical Journal, 60, 56-62
11. Polanska, Y. * and Orimo A.* (2013) Carcinoma Associated Fibroblasts. Journal of Cellular Physiology, 228, 1651-7. *Corresponding author
12. Togo, S.*, Polanska, Y., Horimoto, Y and Orimo, A. * (2013) Carcinoma-associated fibroblasts (CAFs) are a promising therapeutic target. Cancers, 5, 149-169
13. Khan H. and Orimo A.* (2012) TGF-β: guardian of catabolic metabolism in carcinoma-associated fibroblats (CAFs)., Invited News and Views. Cell Cycle, 11, 4-5.
14. Horimoto, Y., Takahashi, T., Polanska, Y. and Orimo, A. * (2012) Emerging roles of the tumour-associated stroma in promoting tumour metastasis., Cell adhesion and migration, 6:3, 193-202
15. Polanska, U., Ahmet A. and Orimo A. * (2011) Experimental generation of carcinoma-associated fibroblasts (CAFs) from human mammary fibroblasts. Journal of Visualized Experiments, (56), e3201, DOI: 10.3791/3201.
16. Shimoda M., Mellody K. and Orimo A. * (2011) The SDF-1-rich tumour microenvironment provides a niche for carcinoma cells., Chapter 13, 245-55, “Tumor-associated fibroblasts and their matrix” edited by Norbert E. Fusenig and Margareta Mueller (ed.), Springer.
17. Polanska, U., Mellody, K. and Orimo A. * (2010) Tumour-promoting stromal myofibroblasts in human carcinomas., Chapter 16, 325-349, "The Tumor Microenvironment, Cancer Drug Discovery and Development" R.G. Bagley (ed.), Springer.
18. Kojima, Y., Acar, A., Eaton, E., Mellody, K., Scheel, C., Ben-Porath, I., Onder, T., Wang, CZ., Richardson, A., Weinberg RA* and Orimo A.* (2010) Autocrine TGF-b and SDF-1 signaling drives evolution of mammary stromal fibroblasts into tumor-promoting myofibroblasts. Proc. Natl. Acad. Sci. USA., 107, 20009-20014.
Faculty 1000に全てのBiologyの論文中トップ10%に選ばれる。
19. Shimoda, M., Mellody, K. & Orimo A. * (2010) Carcinoma-associated fibroblasts are a rate-limiting determinant for tumor progression. Semin Cell Dev Biol., 21, 19-25.
20. Orimo A. and Weinberg RA (2007) Heterogeneity of stromal fibroblasts in tumor. Invited commentary for Sugimoto H. et al, (2006) Identification of fibroblast heterogeneity in the tumor microenvironment, Cancer Biology&Therapy, 5.
21. Orimo A. and Weinberg RA. (2006) Stromal fibroblasts in cancer: a novel tumor-promoting cell type, Cell Cycle, 5, 1602-1606.
2006年のCell Cycleのﾚﾋﾞｭｰ誌の中で、２番目に引用数の多い論文として受賞。
22. Orimo A., Gupta P., Sgroi D., Arenzana-Seisdedos F., Delaunay T., Naeem R., Carey V., Richardson A., and Weinberg RA. (2005) Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion, Cell, 121, 335-348.
5月31日2018年まで2085回引用される。
Laurie E. et al, (2005) Coevolution of cancer and stromal cellular responses, Cancer Cell, 7, 499-500. にプレビューされる。
Furlow B., (2005) Wound healing processes and tumor growth, Lancet Oncology, 6, 363にハイライトされる。
MIT News (http://web.mit.edu/newsoffice/2005/techtalk49-29.pdf)に搭載された。
23. Orimo, A*., Tomioka, Y., Shimizu, Y., Sato, M., Oigawa S., Kamata, K., Nogi, Y., Inoue, S., Takahashi, M., Hata, T., and Muramatsu, M. (2001) Cancer-associated myofibroblasts possess various factors to promote endometrial tumor progression. Clinical Cancer Res. 7, 3097-3105
24. Orimo A*., Yamagishi T., Tominaga N., Yamauchi Y., Hishinuma T., Okada K., Suzuki M., Sato M., Nogi Y., Suzuki H., Inoue S., Yoshimura K., Shimizu Y. and Muramatsu M. (2000) Molecular cloning of testis-abundant finger protein (tfp)/ring finger protein 23 (RNF23); a novel RBCC (RING-B box-coiled coil)-B30.2 protein on the class I region of the human MHC. Biochem. Biophys. Res. Commun. 276, 45-51.
25. Orimo, A., Tominaga, N., Yoshimura, K., Yamauchi, Y., Nomura, M., Sato, M., Nogi, Y., Suzuki, M., Suzuki, H., Ikeda, K., Inoue S., and Muramatsu M. (2000) Molecular cloning of ring finger protein 21 (RNF21)/ interferon-responsive finger protein (ifp1) which possesses two RBCC (RING-B box-coiled coil) domains in tandem. Genomics. 69, 143-9.
26. Ogawa S, Saito T, Matsuda Y, Seki N, Hayashi A, Orimo A, Hosoi T, Ouchi Y, Muramatsu M, Hori T, Inoue S, (2000) Chromosome mapping of RNF16 and Rnf16, human, mouse and rat genes coding for testis RING finger protein (terf), a member of the RING finger family. Cytogenet Cell Genet, 89, 56-58
27. Ogawa S, Fujita M, Ishii Y, Tsurukami H, Hirabayashi M, Ikeda K, Orimo A, Hosoi T, Ueda M, Nakamura T, Ouchi Y, Muramatsu M, Inoue S (2000) Impaired estrogen sensitivity in bone by inhibiting both estrogen receptor (ER) alpha and beta pathways. J. Biol Chem., 275, 21372-21379
28. Ikeda K, Orimo A, Higashi Y, Muramatsu M, Inoue S. (2000) Efp as a primary estrogen-responsive gene in human breast cancer. FEBS Lett., 472, 9-13.
29. Muramatsu M, Ogawa S, Watanabe T, Ikeda, K, Hiroi, H, Orimo A, Inoue S: Recent advances in steroid receptor research: focusing on estrogen receptors (2000) Hormone replacement therapy and osteoporosis (Edited by Kato J, Minaguchi H, Nishio Y) Springer Verlag, Berlin, (pp 43-74).
30. Ikeda K, Inoue S, Orimo A, Hiroi H, Tsuchiya F, Gorai I, Higashi Y, Muramatsu M Expression and Estrogen Inducible Promoter Activity of Human Estrogen-responsive Finger Protein Gene in Breast and Ovarian Cancer Cells. (2000) Hormonal Carcinogenesis III (Edited by Li JJ, Daling JR, Li SA), Springer-Verlag, New York, (pp424-428).
31. Kyo S, Takakura M, Kanaya T, Zhuo W, Fujimoto K, Nishio Y, Orimo A, Inoue M (1999) Estrogen activates telomerase., Cancer Res., 59, 5917-21
32. Orimo, A, Inoue, S., Minowa, O., Tominaga, N., Tomioka, Y., Sato, M., Kuno, K., Hiroi,H., Shimizu, Y., Suzuki, M., Noda T. and Muramatsu, M. (1999) Underdeveloped uterus and reduced estrogen responsiveness in mice with disruption of the estrogen-responsive finger protein (efp) gene, which is a direct target of estrogen receptor a(ER a). Proc. Natl. Acad. Sci. USA., 96, 12027-32
33. Inoue, S., Urano, T., Ogawa, S., Saito, T., Orimo, A., Hoshoi, T., Ouchi, Y. and Muramatsu, M., (1999) Molecular cloning of rat efp: expression and regulation in primary osteoblasts. Biochem. Biophys. Res. Commun., 261, 412-8.
34. Orimo, A., Tominaga, N., Suzuki, M., Kawakami, T., Kuno, J., Sato, M., Minowa, O., Inoue, S., Kato, S., Noda, T., Muramatsu, M. (1999) Successful germ-line transmission of chimeras generated by coculture aggregation with J1 ES cells and eight-cell embryos. Anal Biochem, 269, 204-207
35. Hiroi H, Inoue S, Watanabe T, Goto W, Orimo A, Momoeda M, Tsutsumi O, Taketani Y., Muramatsu M., (1999) Differential immunolocalization of estrogen receptor alpha and beta in rat ovary an uterus., J. Mol. Endocrinol., 22, 37-44
36. Watanabe T, Inoue S, Hiroi H, Orimo A, Muramatsu M., (1999) NMDA receptor type 2D gene as target for estrogen receptor in the brain., Brain Res. Mol. Brain Res. 63, 375-379
37. Orimo, A., Inoue, S., Ikeda, K., Sato, M., Kato, A., Tominaga, N., Suzuki, M., Noda T., Watanabe, M., Muramatsu, M. (1998) Molecular cloning, localization and developmental expression of mouse brain finger protein (bfp); distribution of bfp mRNA partially coincides with the affected areas of Smith-Magenis Syndrome (SMS). Genomics, 54, 59-69
38. Watanabe, T., Inoue, S., Hiroi, H., Orimo, A., Kawashima, H. and Muramatsu, M., (1998) Isolation of estrogen-responsive genes with a CpG island library. Mol. Cell. Biol., 18, 442-449.
39. Okuda, A., Fukushima, A., Nishimoto, M., Orimo, A., Yamagishi, T., Nabeshima, Y., Kuro-o, M., Nabeshima, Y., Boon, K., Keaveney, M., Stunnenberg, H.G., Muramatsu, M. (1998) UTF1, a novel transcriptional coactivator expressed in pluripotent embryonic stem cells and extra-embryonic cells. EMBO J., 17, 2019-2032.
40. Ogawa S, Inoue S, Watanabe T, Orimo A, Hosoi T, Ouchi Y, Muramatsu M, (1998) Molecular cloning and characterization of human estrogen receptor betacx: a potential inhibitor of estrogen action in human., Nucleic. Acids. Res., 26, 3505-3512.
41. Ogawa, S., Inoue, S., Watanabe, T., Hiroi, H., Orimo, A., Hosoi, T., Ouchi, Y., Muramatsu, M. (1998) The complete primary structure of human estrogen receptor b (ER b) and its heterodimerization with ER a in vivo and in vitro. Biochem.Biophys.Res Commun, 243, 122-126.
42. Ogawa, S., Inoue, S., Orimo, A., Hosoi, T., Ouchi, Y., Muramatsu, M., (1998) Cross inhibition of both estrogen receptor alpha and beta pathways by each dominant negative mutant. FEBS Lett, 423, 129-132.
43. Ikeda, K., Inoue, S., Orimo, A., Tsutsumi, K., Muramatsu, M., (1998) Promotor analysis of mouse estrogen-responsive finger protein (efp) gene: mouse efp promotor contains an E-box that is also conserved in human. Gene, 216, 155-162
44. Ogawa S, Goto W, Orimo A, Hosoi T, Ouchi Y, Muramatsu M, Inoue S. (1998) Molecular cloning of a novel RING finger-B box-coiled coil (RBCC) protein, terf, expressed in the testis., Biochem Biophys Res Commun., 251, 515-519
45. Kimura, T., Arakawa, Y., Inoue, S., Fukushima, Y., Kondo, I., Koyama., K., Hosoi, T., Orimo, A., Muramatsu, M., Nkamura, Y., Abe, T. and Inazawa, J. (1997) The brain finger protein gene (ZNF179), a member of the RING finger family, maps within the Smith-magenis syndrome region at 17p112., American Journal of Medical Genetics 69, 320-324.
46. Watanabe, T., Inoue, S., Ogawa, S., Ishii, Y., Hiroi, H., Ikeda, K., Orimo, A. and Muramatsu, M., (1997) Agonistic effect of Tamoxifen is dependent on cell type, ERE-promoter context, and Estrogen receptor subtype: functional difference between estrogen receptor a and b. Biochem. Biophys. Res. Commun., 236, 140-145.
47. Ikeda, K., Inoue, S., Orimo, A., Sano, M., Watanabe, T., Tsutsumi, K., and Muramatsu, M., (1997) Multiple regulatory elements and binding proteins of the 5’-flanking region of the human estrogen-responsive finger protein (efp) gene. Biochem.Biophys.Res.Commun., 236, 765-771.
48. Inoue, S., Orimo, A., Saito, T., Ikeda, K., Sakata, K., Hosoi, T., Orimo, H., Ouchi, Y. and Muramatsu, M. (1997) A novel ring finger protein, BFP predominantly expressed in the brain, Biochem. Biophys. Res. Commun., 240, 8-14.
49. Ogawa, S., Inoue, S., Watanabe, T., Hiroi, H., Orimo, A., Hosoi, T., Ouchi, Y., Muramastsu, M., (1997) Molecular cloning and functional analysis of human estrogen receptor beta 2., J. Bone and Mineral Res., 12, P255.
50. Matsuda, Y., Inoue, S., Seki, N., Hosoi, T., Orimo, A., Muramatsu, M. and Hori, T., (1996) Chromosome mapping of human (ZNF197), mouse and rat genes for brain finger protein (bfp), a member of the RING finger family. Genomics, 33, 325-327.
51. Akisita, M., Ouchi, Y., Miyoshi, H., Orimo, A., et al., (1996) Estrogen inhibits endothelin-1 production and c-fos gene expression in rat aorta., Atherosclerosis, 125, 27-38.
52. Orimo, A., Inoue, S., Ikeda, K., Noji, S. and Muramatsu, M. (1995) Molecular cloning, structure and expression of mouse estrogen-responsive finger protein (efp); co-localization with estrogen receptor mRNA in target organs. J. Biol. Chem., 270, 24406-24413.
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