～2018

1. Yu Okazawa, Kosuke Mizukoshi, Yu Koyama, Shoki Okubo, Hiromitsu Komiyama, Yutaka Kojima, Michitoshi Goto, Sonoko Habu, Okio Hino, Kazuhiro Sakamoto* and Akira Orimo*  (2018) High-sensitivity detection of micrometastases generated by GFP lentivirus-transduced organoids cultured from a patient-derived colon tumor. Journal of Visualized Experiments. 14;(136). doi:10.3791/57374. * Corresponding author 

2. Pernilla Roswall, Matteo Bocci, Michael Bartoschek, Hong Li, Glen Kristiansen, Sara Jansson, Sophie Lehn, Jonas Sjölund, Steven Reid, Christer Larsson, Pontus Eriksson, Charlotte Anderberg, Eliane Cortez, Lao H Saal, Christina Orsmark-Pietras, Eugenia Cordero, B Kristian Haller, Jari Häkkinen, Ingrid JG Burvenich, Elgene Lim, Akira Orimo, Mattias Höglund, Lisa Rydén, Holger Moch, Andrew M Scott, Ulf Eriksson, Kristian Pietras,  (2018) Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling., Nature Medicine. doi: 10.1038/nm.4494.

3. Tomokatsu Omoto, Joo-ri Kim-Kaneyama, Xiao-Feng Lei, Akira Orimo, Koji Ohnishi, Kosuke Yoshihara, Aya Miyauchi, Shuo Li, Lin Gao, Takahiro Umemoto, Junichi Tanaka, Kenta Nakahara, Motohiro Takeya, Fumio Ishida, Shin-ei Kudo, Shogo Haraguchi, Takuro Miyazaki and Akira Miyazaki. (2017) The impact of stromal Hic-5 on the tumorigenesis of colorectal cancer through lysyl oxidase induction and stromal remodeling. Oncogene, doi: 10.1038/s41388-017-0033-y 

4. Nakaoka HJ, Tanei Z, Hara T, Weng JS, Kanamori A, Hayashi T, Sato H, Orimo A, Otsuji K, Tada K, Morikawa T, Sasaki T, Fukayama M, Seiki M, Murakami Y, Sakamoto T. (2017) Mint3-mediated L1CAM expression in fibroblasts promotes cancer cell proliferation via integrin α5β1 and tumour growth. Oncogenesis. 6(5):e334. 

5. Namba Y, Togo S, Tulafu M, Kadoya K, Nagahama KY, Taka H, Kaga N, Orimo A, Liu X, Takahashi K. (2017) Combination of glycopyrronium and indacaterol inhibits carbachol-induced ERK5 signal in fibrotic processes., Respir Res. 18, 46.

6. Escudero-Esparza A., Bartoschek M., Gialeli C., Okroj M., Owen S., Jirström K., Orimo A., Jiang WG., Pietras K., Blom AM., (2016) Complement inhibitor CSMD1 acts as tumor suppressor in human breast cancer. Oncotarget, 2016, 7, 76920-76933

7. Mezawa, Y. and Orimo A*., The roles of tumor- and metastasis-promoting carcinoma-associated fibroblasts in human carcinomas. Cell and tissue research, (2016), 365, 675-89. doi: 10.1007/s00441-016-2471-1. * Corresponding author 

8. Englund E, Bartoschek M, Reitsma B, Jacobsson L, Escudero-Esparza A, Orimo A, Leandersson K, Hagerling C, Aspberg A, Storm P, Okroj M, Mulder H, Jirström K, Pietras K, Blom AM. (2016) Cartilage oligomeric matrix protein contributes to the development and metastasis of breast cancer. Oncogene. 235, 5585-5596 doi: 10.1038/onc.2016.98

9. Holmquist E., Reitsma B., King B., Escudero-Esparza Sioned Owen A., Orimo A., Okroj M., Anagnostaki L., Jiang W., Jirström K., Blom A., The human complement inhibitor Sushi Domain-Containing Protein 4 (SUSD4) expression in tumor cells and CD8+ T cells is associated with better prognosis of breast cancer patients. BMC Cancer, (2015) 19, 737.　 

10. Orimo A., (2014) The biology of tumour metastasis, Lecture Note, Juntendo Medical Journal, 60, 56-62

11. Polanska, Y. * and Orimo A.* (2013) Carcinoma Associated Fibroblasts. Journal of Cellular Physiology, 228, 1651-7. *Corresponding author　

12. Togo, S.*, Polanska, Y., Horimoto, Y and Orimo, A. * (2013) Carcinoma-associated fibroblasts (CAFs) are a promising therapeutic target. Cancers, 5, 149-169

13. Khan H. and Orimo A.* (2012) TGF-β: guardian of catabolic metabolism in carcinoma-associated fibroblats (CAFs)., Invited News and Views. Cell Cycle, 11, 4-5. 

14. Horimoto, Y., Takahashi, T., Polanska, Y. and Orimo, A. * (2012) Emerging roles of the tumour-associated stroma in promoting tumour metastasis., Cell adhesion and migration, 6:3, 193-202 

15. Polanska, U., Ahmet A. and Orimo A. * (2011) Experimental generation of carcinoma-associated fibroblasts (CAFs) from human mammary fibroblasts. Journal of Visualized Experiments, (56), e3201, DOI: 10.3791/3201.

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16. Shimoda M., Mellody K. and Orimo A. * (2011) The SDF-1-rich tumour microenvironment provides a niche for carcinoma cells., Chapter 13, 245-55, “Tumor-associated fibroblasts and their matrix” edited by Norbert E. Fusenig and Margareta Mueller (ed.), Springer. 

17. Polanska, U., Mellody, K. and Orimo A. * (2010) Tumour-promoting stromal myofibroblasts in human carcinomas., Chapter 16, 325-349, "The Tumor Microenvironment, Cancer Drug Discovery and Development" R.G. Bagley (ed.), Springer.

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18. Kojima, Y., Acar, A., Eaton, E., Mellody, K., Scheel, C., Ben-Porath, I., Onder, T., Wang, CZ., Richardson, A., Weinberg RA* and Orimo A.* (2010) Autocrine TGF-b and SDF-1 signaling drives evolution of mammary stromal fibroblasts into tumor-promoting myofibroblasts. Proc. Natl. Acad. Sci. USA., 107, 20009-20014.

Faculty 1000に全てのBiologyの論文中トップ10%に選ばれる。

19. Shimoda, M., Mellody, K. & Orimo A. * (2010) Carcinoma-associated fibroblasts are a rate-limiting determinant for tumor progression. Semin Cell Dev Biol., 21, 19-25. 

20. Orimo A. and Weinberg RA (2007) Heterogeneity of stromal fibroblasts in tumor. Invited commentary for Sugimoto H. et al, (2006) Identification of fibroblast heterogeneity in the tumor microenvironment, Cancer Biology&Therapy, 5. 

21. Orimo A. and Weinberg RA. (2006) Stromal fibroblasts in cancer: a novel tumor-promoting cell type, Cell Cycle, 5, 1602-1606.

2006年のCell Cycleのﾚﾋﾞｭｰ誌の中で、２番目に引用数の多い論文として受賞。

22. Orimo A., Gupta P., Sgroi D., Arenzana-Seisdedos F., Delaunay T., Naeem R., Carey V., Richardson A., and Weinberg RA. (2005) Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion, Cell, 121, 335-348.

5月31日2018年まで2085回引用される。

Laurie E. et al, (2005) Coevolution of cancer and stromal cellular responses, Cancer Cell, 7, 499-500. にプレビューされる。

Furlow B., (2005) Wound healing processes and tumor growth, Lancet Oncology, 6, 363にハイライトされる。

MIT News (http://web.mit.edu/newsoffice/2005/techtalk49-29.pdf)に搭載された。

23. Orimo, A*., Tomioka, Y., Shimizu, Y., Sato, M., Oigawa S., Kamata, K., Nogi, Y., Inoue, S., Takahashi, M., Hata, T., and Muramatsu, M. (2001) Cancer-associated myofibroblasts possess various factors to promote endometrial tumor progression. Clinical Cancer Res. 7, 3097-3105

24. Orimo A*., Yamagishi T., Tominaga N., Yamauchi Y., Hishinuma T., Okada K., Suzuki M., Sato M., Nogi Y., Suzuki H., Inoue S., Yoshimura K., Shimizu Y. and Muramatsu M. (2000) Molecular cloning of testis-abundant finger protein (tfp)/ring finger protein 23 (RNF23); a novel RBCC (RING-B box-coiled coil)-B30.2 protein on the class I region of the human MHC. Biochem. Biophys. Res. Commun. 276, 45-51. 

25. Orimo, A., Tominaga, N., Yoshimura, K., Yamauchi, Y., Nomura, M., Sato, M., Nogi, Y., Suzuki, M., Suzuki, H., Ikeda, K., Inoue S., and Muramatsu M. (2000) Molecular cloning of ring finger protein 21 (RNF21)/ interferon-responsive finger protein (ifp1) which possesses two RBCC (RING-B box-coiled coil) domains in tandem. Genomics. 69, 143-9. 

26. Ogawa S, Saito T, Matsuda Y, Seki N, Hayashi A, Orimo A, Hosoi T, Ouchi Y, Muramatsu M, Hori T, Inoue S, (2000) Chromosome mapping of RNF16 and Rnf16, human, mouse and rat genes coding for testis RING finger protein (terf), a member of the RING finger family. Cytogenet Cell Genet, 89, 56-58 

27. Ogawa S, Fujita M, Ishii Y, Tsurukami H, Hirabayashi M, Ikeda K, Orimo A, Hosoi T, Ueda M, Nakamura T, Ouchi Y, Muramatsu M, Inoue S (2000) Impaired estrogen sensitivity in bone by inhibiting both estrogen receptor (ER) alpha and beta pathways. J. Biol Chem., 275, 21372-21379 

28. Ikeda K, Orimo A, Higashi Y, Muramatsu M, Inoue S. (2000) Efp as a primary estrogen-responsive gene in human breast cancer. FEBS Lett., 472, 9-13. 

29. Muramatsu M, Ogawa S, Watanabe T, Ikeda, K, Hiroi, H, Orimo A, Inoue S: Recent advances in steroid receptor research: focusing on estrogen receptors (2000) Hormone replacement therapy and osteoporosis (Edited by Kato J, Minaguchi H, Nishio Y) Springer Verlag, Berlin, (pp 43-74).

30. Ikeda K, Inoue S, Orimo A, Hiroi H, Tsuchiya F, Gorai I, Higashi Y, Muramatsu M Expression and Estrogen Inducible Promoter Activity of Human Estrogen-responsive Finger Protein Gene in Breast and Ovarian Cancer Cells. (2000) Hormonal Carcinogenesis III (Edited by Li JJ, Daling JR, Li SA), Springer-Verlag, New York, (pp424-428).

31. Kyo S, Takakura M, Kanaya T, Zhuo W, Fujimoto K, Nishio Y, Orimo A, Inoue M (1999) Estrogen activates telomerase., Cancer Res., 59, 5917-21 

32. Orimo, A, Inoue, S., Minowa, O., Tominaga, N., Tomioka, Y., Sato, M., Kuno, K., Hiroi,H., Shimizu, Y., Suzuki, M., Noda T. and Muramatsu, M. (1999) Underdeveloped uterus and reduced estrogen responsiveness in mice with disruption of the estrogen-responsive finger protein (efp) gene, which is a direct target of estrogen receptor a(ER a). Proc. Natl. Acad. Sci. USA., 96, 12027-32 

33. Inoue, S., Urano, T., Ogawa, S., Saito, T., Orimo, A., Hoshoi, T., Ouchi, Y. and Muramatsu, M., (1999) Molecular cloning of rat efp: expression and regulation in primary osteoblasts. Biochem. Biophys. Res. Commun., 261, 412-8. 

34. Orimo, A., Tominaga, N., Suzuki, M., Kawakami, T., Kuno, J., Sato, M., Minowa, O., Inoue, S., Kato, S., Noda, T., Muramatsu, M. (1999) Successful germ-line transmission of chimeras generated by coculture aggregation with J1 ES cells and eight-cell embryos. Anal Biochem, 269, 204-207

35. Hiroi H, Inoue S, Watanabe T, Goto W, Orimo A, Momoeda M, Tsutsumi O, Taketani Y., Muramatsu M., (1999) Differential immunolocalization of estrogen receptor alpha and beta in rat ovary an uterus., J. Mol. Endocrinol., 22, 37-44 
 

36. Watanabe T, Inoue S, Hiroi H, Orimo A, Muramatsu M., (1999) NMDA receptor type 2D gene as target for estrogen receptor in the brain., Brain Res. Mol. Brain Res. 63, 375-379 

37. Orimo, A., Inoue, S., Ikeda, K., Sato, M., Kato, A., Tominaga, N., Suzuki, M., Noda T., Watanabe, M., Muramatsu, M. (1998) Molecular cloning, localization and developmental expression of mouse brain finger protein (bfp); distribution of bfp mRNA partially coincides with the affected areas of Smith-Magenis Syndrome (SMS). Genomics, 54, 59-69 

38. Watanabe, T., Inoue, S., Hiroi, H., Orimo, A., Kawashima, H. and Muramatsu, M., (1998) Isolation of estrogen-responsive genes with a CpG island library. Mol. Cell. Biol., 18, 442-449. 

39. Okuda, A., Fukushima, A., Nishimoto, M., Orimo, A., Yamagishi, T., Nabeshima, Y., Kuro-o, M., Nabeshima, Y., Boon, K., Keaveney, M., Stunnenberg, H.G., Muramatsu, M. (1998) UTF1, a novel transcriptional coactivator expressed in pluripotent embryonic stem cells and extra-embryonic cells. EMBO J., 17, 2019-2032. 

40. Ogawa S, Inoue S, Watanabe T, Orimo A, Hosoi T, Ouchi Y, Muramatsu M, (1998) Molecular cloning and characterization of human estrogen receptor betacx: a potential inhibitor of estrogen action in human., Nucleic. Acids. Res., 26, 3505-3512. 

41. Ogawa, S., Inoue, S., Watanabe, T., Hiroi, H., Orimo, A., Hosoi, T., Ouchi, Y., Muramatsu, M. (1998) The complete primary structure of human estrogen receptor b (ER b) and its heterodimerization with ER a in vivo and in vitro. Biochem.Biophys.Res Commun, 243, 122-126. 

42. Ogawa, S., Inoue, S., Orimo, A., Hosoi, T., Ouchi, Y., Muramatsu, M., (1998) Cross inhibition of both estrogen receptor alpha and beta pathways by each dominant negative mutant. FEBS Lett, 423, 129-132. 

43. Ikeda, K., Inoue, S., Orimo, A., Tsutsumi, K., Muramatsu, M., (1998) Promotor analysis of mouse estrogen-responsive finger protein (efp) gene: mouse efp promotor contains an E-box that is also conserved in human. Gene, 216, 155-162 

44. Ogawa S, Goto W, Orimo A, Hosoi T, Ouchi Y, Muramatsu M, Inoue S. (1998) Molecular cloning of a novel RING finger-B box-coiled coil (RBCC) protein, terf, expressed in the testis., Biochem Biophys Res Commun., 251, 515-519 

45. Kimura, T., Arakawa, Y., Inoue, S., Fukushima, Y., Kondo, I., Koyama., K., Hosoi, T., Orimo, A., Muramatsu, M., Nkamura, Y., Abe, T. and Inazawa, J. (1997) The brain finger protein gene (ZNF179), a member of the RING finger family, maps within the Smith-magenis syndrome region at 17p112., American Journal of Medical Genetics 69, 320-324. 

46. Watanabe, T., Inoue, S., Ogawa, S., Ishii, Y., Hiroi, H., Ikeda, K., Orimo, A. and Muramatsu, M., (1997) Agonistic effect of Tamoxifen is dependent on cell type, ERE-promoter context, and Estrogen receptor subtype: functional difference between estrogen receptor a and b. Biochem. Biophys. Res. Commun., 236, 140-145. 

47. Ikeda, K., Inoue, S., Orimo, A., Sano, M., Watanabe, T., Tsutsumi, K., and Muramatsu, M., (1997) Multiple regulatory elements and binding proteins of the 5’-flanking region of the human estrogen-responsive finger protein (efp) gene. Biochem.Biophys.Res.Commun., 236, 765-771. 

48. Inoue, S., Orimo, A., Saito, T., Ikeda, K., Sakata, K., Hosoi, T., Orimo, H., Ouchi, Y. and Muramatsu, M. (1997) A novel ring finger protein, BFP predominantly expressed in the brain, Biochem. Biophys. Res. Commun., 240, 8-14. 

49. Ogawa, S., Inoue, S., Watanabe, T., Hiroi, H., Orimo, A., Hosoi, T., Ouchi, Y., Muramastsu, M., (1997) Molecular cloning and functional analysis of human estrogen receptor beta 2., J. Bone and Mineral Res., 12, P255. 

50. Matsuda, Y., Inoue, S., Seki, N., Hosoi, T., Orimo, A., Muramatsu, M. and Hori, T., (1996) Chromosome mapping of human (ZNF197), mouse and rat genes for brain finger protein (bfp), a member of the RING finger family. Genomics, 33, 325-327. 

51. Akisita, M., Ouchi, Y., Miyoshi, H., Orimo, A., et al., (1996) Estrogen inhibits endothelin-1 production and c-fos gene expression in rat aorta., Atherosclerosis, 125, 27-38. 

52. Orimo, A., Inoue, S., Ikeda, K., Noji, S. and Muramatsu, M. (1995) Molecular cloning, structure and expression of mouse estrogen-responsive finger protein (efp); co-localization with estrogen receptor mRNA in target organs. J. Biol. Chem., 270, 24406-24413. 

53. Orimo, A., Inoue, S., Ouchi, Y. and Orimo, H. (1995) Vascular smooth muscle cells possess estrogen receptor and respond to estrogen. Ann. N. Y. Acad. Sci., 748, 592-594. 

54. Inoue, S., Orimo, A., Hosoi, T., Matsuse, T., Kozaki, K., Ouchi, Y., Orimo, H. and Muramatsu, M. (1995) Follistatin as an activin-binding protein expressed in arteriosclerotic lesions. Ann. N. Y. Acad. Sci., 748, 530-533. 

55. Inoue, S., Orimo, A., Matsuda, Y., Inazawa, J., Emi, M., Nakamura, Y., Hori, T. and Muramatsu, M. (1995) Chromosome mappings of human and mouse genes for estrogen-responsive finger protein (efp), a member of the RING finger family. Genomics, 25, 581-583. 

56. Orimo, A., Inouse, S., Hoshino, S., Saito, T., Ikegami, A., Kaneki, M., Hoshoi, T., Ouchi, Y., Muramatsu, M., Orimo H., (1995) Identification of isoforms of estrogen-receptor messenger RNA in the bone tissues, J. Bone and Mineral Res., 10, S391, 

57. Inoue, S., Orimo, A., Hosoi, T., Ikegami, A., Kozaki, K., Ouchi, Y., Nomura, S., Muramatsu, M. and Orimo, H. (1994) Demonstration of activin-A in arteriosclerotic lesions. Biochem. Biophys. Res. Commun., 205, 441-448. 

58. Orimo, A., Inoue, S., Ikegami, A., Hosoi, T., Akishita, M., Ouchi, Y., Muramatsu, M. and Orimo, H. (1993) Vascular smooth muscle cells as target for estrogen. Biochem. Biophys. Res. Commun.,195, 730-736.

59. Inoue, S., Orimo, A., Hosoi, T., Kondo, S., Toyoshima, H., Kondo, T., Ikegami, A., Ouchi, Y., Orimo, H. and Muramatsu, M. (1993) Genomic binding-site cloning reveals a novel estrogen responsive gene that encodes a RING finger protein. Proc. Natl. Acad. Sci. USA., 90, 11117-11121. 

60. Inoue, S., Orimo, A., Hosoi, T., Matsuse, T., Hashimoto, M., Yamada, R., Ouchi, Y., Orimo, H. and Muramatsu, M. (1993) Expression of follistatin, an activin-binding protein in vascular smooth muscle cells and in arteriosclerotic lesions. Arterioscler. Thromb.13,1859-1864. 

61. Akishita M, Ouchi Y, Kozaki K, Orimo A, Hattori A, Orimo H., (1992) Accuracy and reliability of quantitative measurement of coronary arterial stenosis by videodensitometry on coronary angiogram., Jpn. Heart J., 33, 631-641.